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DeCS
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Descritor Inglês:
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Metabolic Detoxication, Phase I
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Descritor Espanhol:
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Fase I de la Desintoxicación Metabólica
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Descritor Português:
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Desentoxicação Metabólica Fase I
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Sinônimos Inglês:
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Detoxication, Oxidative Metabolic
Detoxications, Oxidative Metabolic
Detoxification, Phase I
Detoxifications, Phase I
Metabolic Detoxication, Oxidative
Metabolic Detoxications, Oxidative
Metabolic Detoxification, Phase I
Oxidative Metabolic Detoxication
Oxidative Metabolic Detoxications
Phase I Detoxification
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Categoria:
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G03.171.450.500
G03.787.225.450.500
G07.690.725.225.450.500
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Definição Inglês:
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Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS. |
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Relacionados Inglês:
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Drug Interactions
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Nota Histórica Inglês:
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2006
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Qualificadores Permitidos Inglês:
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Número do Registro:
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51246
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Identificador Único:
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D050216
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Ocorrência na BVS:
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DeCS
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